Tyrosine

Tyrosine

SCHEMBL15670892

N[C@@H](Cc1ccc(O)cc1)C(=O)O.O=C(O)/C=C/c1ccc(O)cc1

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 3/20 0.71
ESR1 P03372 3/20 0.62
PKM P14618 2/20 0.62
AKR1B10 O60218 2/20 0.62
AKR1B1 P15121 2/20 0.62
TYR P14679 2/20 0.62
ESR2 Q92731 2/20 0.62
CA12 O43570 1/20 0.62
CA1 P00915 1/20 0.62
CA2 P00918 1/20 0.62
CA3 P07451 1/20 0.62
CA4 P22748 1/20 0.62
CA6 P23280 1/20 0.62
DPP4 P27487 1/20 0.62
CA5A P35218 1/20 0.62
CA7 P43166 1/20 0.62
CA9 Q16790 1/20 0.62
HCAR2 Q8TDS4 1/20 0.62
CA14 Q9ULX7 1/20 0.62
CA5B Q9Y2D0 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrosine SCHEMBL17023915 0.99 SLC7A5 (0.69) SLC7A5ESR1PKMAKR1B10AKR1B1
Tyrosine SCHEMBL4613087 0.93 SLC7A5 (0.61) SLC7A5ESR1PKMAKR1B10AKR1B1
Tyrosine SCHEMBL4613098 0.93 SLC7A5 (0.61) SLC7A5ESR1PKMAKR1B10AKR1B1
Tyrosine SCHEMBL25429176 0.90 KDM4E (0.60) SLC7A5ESR1PKMAKR1B10AKR1B1
Tyrosine SCHEMBL25429180 0.90 KDM4E (0.60) SLC7A5ESR1PKMAKR1B10AKR1B1
Tyrosine SCHEMBL7050049 0.86 SLC7A5 (0.52) SLC7A5ESR1PKMAKR1B10AKR1B1
Tyrosine SCHEMBL7050041 0.86 SLC7A5 (0.52) SLC7A5ESR1PKMAKR1B10AKR1B1
SCHEMBL15670893 0.85 SLC7A5 (0.61) SLC7A5PKMAKR1B10AKR1B1TYR
Phenylalanine SCHEMBL8012741 0.85 SLC7A5 (0.69) SLC7A5PKMHCAR2BACE1PTGS1
Phenylalanine SCHEMBL8012746 0.85 SLC7A5 (0.69) SLC7A5PKMHCAR2BACE1PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2914733-A1 VANILLIN SYNTHASE Evolva SA (CH) 2015-09-09 EP disclosed
WO-2014067534-A1 VANILLIN SYNTHASE EVOLVA SA (CH) 2014-05-08 WO disclosed