Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.74 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.74 |
| ▸ | MERTK | Q12866 | 1/20 | 0.66 |
| ▸ | JAK2 | O60674 | 14/20 | 0.65 |
| ▸ | JAK1 | P23458 | 13/20 | 0.65 |
| ▸ | JAK3 | P52333 | 5/20 | 0.65 |
| ▸ | RET | P07949 | 3/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.65 |
| ▸ | TYK2 | P29597 | 3/20 | 0.65 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.65 |
| ▸ | PAK4 | O96013 | 2/20 | 0.65 |
| ▸ | ABL1 | P00519 | 2/20 | 0.65 |
| ▸ | LTK | P29376 | 2/20 | 0.65 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.65 |
| ▸ | CLK2 | P49760 | 2/20 | 0.65 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.65 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.65 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.65 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15934905 | 0.91 | AXL (0.71) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL13074738 | 0.90 | AXL (0.77) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL859513 | 0.90 | AXL (0.74) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL860582 | 0.90 | AXL (0.76) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL859327 | 0.90 | AXL (0.81) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL13058423 | 0.89 | AXL (0.67) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL859878 | 0.88 | AXL (0.71) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL859425 | 0.88 | AXL (0.71) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL13074730 | 0.87 | AXL (0.79) | AXLTYRO3MERTKJAK2JAK1 | |
| SCHEMBL3751982 | 0.87 | AXL (0.79) | AXLTYRO3MERTKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432555-B1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-D]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-D]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORP (US) | 2014-04-30 | — | — | EP | disclosed |