Trandolaprilat

Trandolaprilat

SCHEMBL156829

C[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N1[C@@H]2CCCC[C@H]2C[C@H]1C(=O)O

nearest known ligand 0.82

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Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ACE P12821 14/20 0.82
MEN1 O00255 2/20 0.82
KMT2A Q03164 2/20 0.82
USP2 O75604 1/20 0.82
LMNA P02545 1/20 0.82
CYP3A4 P08684 1/20 0.79
ALOX15 P16050 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trandolaprilat SCHEMBL11076552 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL678354 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL5567196 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL9173132 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL683838 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL9173121 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL11286342 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL5794079 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL9173113 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL7388097 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200276166-A1 METHODS OF TREATING NEUROLOGICAL DISORDERS UNIV CALIFORNIA (US) 2020-09-03 US disclosed
US-10668049-B2 Methods of treating cognitive decline with transforming growth factor beta inhibitors THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-06-02 US disclosed
US-20160367530-A1 METHODS OF TREATING NEUROLOGICAL DISORDERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2016-12-22 US disclosed
US-9468649-B2 Methods of treating epilepsy with transforming growth factor beta inhibitors THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-10-18 US disclosed
US-20120058949-A1 Methods of Treating Neurological Disorders THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2012-03-08 US disclosed
WO-2010065917-A1 METHODS OF TREATING NEUROLOGICAL DISORDERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-06-10 WO disclosed
US-20060286105-A1 Tgf-beta antagonists combined with renin-angiotensin-aldosteron-system antagonists for treating renal insufficiency LEDBETTER STEVEN 2006-12-21 US disclosed
EP-1620128-A1 TGF-BETA ANTAGONISTS COMBINED WITH RENIN-ANGIOTENSIN-ALDOSTERON-SYSTEM ANTAGONISTS FOR TREATING RENAL INSUFFICIENCY GENZYME CORPORATION (US) 2006-02-01 EP disclosed
WO-2004098637-A1 TGF-BETA ANTAGONISTS COMBINED WITH RENIN-ANGIOTENSIN-ALDOSTERON-SYSTEM ANTAGONISTS FOR TREATING RENAL INSUFFICIENCY GENZYME CORPORATION (US) 2004-11-18 WO disclosed