Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.75 |
| ▸ | JAK1 | P23458 | 16/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26629703 | 0.90 | TYK2 (0.78) | TYK2JAK1KCNH2 | |
| SCHEMBL30636403 | 0.90 | TYK2 (0.78) | TYK2JAK1KCNH2 | |
| SCHEMBL15713476 | 0.86 | TYK2 (1.00) | TYK2JAK1KCNH2 | |
| SCHEMBL15713485 | 0.84 | TYK2 (0.69) | TYK2JAK1KCNH2 | |
| SCHEMBL30636208 | 0.83 | TYK2 (0.72) | TYK2JAK1 | |
| SCHEMBL16712862 | 0.83 | TYK2 (0.72) | TYK2JAK1 | |
| SCHEMBL15713489 | 0.83 | TYK2 (0.76) | TYK2JAK1KCNH2 | |
| SCHEMBL15713570 | 0.83 | TYK2 (0.68) | TYK2JAK1KCNH2 | |
| SCHEMBL15713486 | 0.83 | TYK2 (0.71) | TYK2JAK1KCNH2 | |
| SCHEMBL15713491 | 0.83 | TYK2 (0.79) | TYK2JAK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922841-B1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL MYERS SQUIBB CO (US) | 2017-06-07 | — | — | EP | disclosed |
| US-9315494-B2 | Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-19 | — | — | US | disclosed |
| US-9315494-B2 | Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-19 | — | — | US | disclosed |
| WO-2014074660-A1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNα RESPONSES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-05-15 | — | — | WO | disclosed |