Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15713886 | 0.82 | PDE10A (1.00) | PDE10A | |
| SCHEMBL15560448 | 0.79 | PDE10A (1.00) | PDE10A | |
| SCHEMBL15691935 | 0.75 | PDE10A (0.60) | PDE10A | |
| SCHEMBL15538463 | 0.75 | PDE10A (1.00) | PDE10A | |
| SCHEMBL15538187 | 0.74 | PDE10A (1.00) | PDE10A | |
| SCHEMBL15539150 | 0.74 | PDE10A (1.00) | PDE10A | |
| SCHEMBL15538456 | 0.72 | PDE10A (1.00) | PDE10A | |
| SCHEMBL15551001 | 0.68 | PDE10A (1.00) | PDE10A | |
| SCHEMBL15714046 | 0.68 | PDE10A (0.77) | PDE10A | |
| SCHEMBL26616474 | 0.67 | PDE10A (0.56) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617271-B2 | Triazolo compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-04-11 | — | — | US | disclosed |
| US-9617271-B2 | Triazolo compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-04-11 | — | — | US | disclosed |
| EP-2916842-B1 | TRIAZOLO COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2016-10-19 | — | — | EP | disclosed |
| US-20150232472-A1 | TRIAZOLO COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-08-20 | — | — | US | disclosed |
| US-20150232472-A1 | TRIAZOLO COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-08-20 | — | — | US | disclosed |
| WO-2014072261-A1 | TRIAZOLO COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232472-A1 | TRIAZOLO COMPOUNDS | GRIK5, NLN, GRIN2C | PDE10A 805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.