Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | STAT1 | P42224 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15716909 | 0.87 | BRD4 (0.42) | L3MBTL1BRD4KDM4EALDH1A1TDP1 | |
| SCHEMBL18129934 | 0.86 | PARP1 (0.40) | L3MBTL1BRD4 | |
| SCHEMBL15716821 | 0.86 | KDM4E (0.45) | BRD4KDM4EALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL15716545 | 0.85 | BRD4 (0.44) | L3MBTL1BRD4KDM4EALDH1A1TDP1 | |
| SCHEMBL15716820 | 0.82 | KDM4E (0.39) | L3MBTL1BRD4KDM4EALDH1A1TDP1 | |
| SCHEMBL18598777 | 0.82 | CA12 (0.40) | L3MBTL1BRD4LMNA | |
| SCHEMBL15716945 | 0.81 | PIK3CD (0.33) | L3MBTL1BRD4KDM4EALDH1A1BRD9 | |
| SCHEMBL15716555 | 0.81 | KCNH2 (0.41) | BRD4KDM4ESMN1; SMN2KCNH2HSD17B10 | |
| SCHEMBL15716757 | 0.80 | KCNH2 (0.41) | BRD4KDM4ETDP1SMN1; SMN2KCNH2 | |
| SCHEMBL15716674 | 0.80 | BRD4 (0.33) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920183-A1 | THIENO[3,2-C]PYRIDIN-4(5H)-ONES AS BET INHIBITORS | Glaxosmithkline LLC (US) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014078257-A1 | THIENO[3,2-C]PYRIDIN-4(5H)-ONES AS BET INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-05-22 | — | — | WO | disclosed |