Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 5/20 | 0.58 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572123 | 1.00 | HCRTR1 (0.58) | HCRTR1HCRTR2MAPK1ALOX15 | |
| SCHEMBL1572277 | 0.88 | HCRTR1 (0.60) | HCRTR1HCRTR2MAPK1 | |
| SCHEMBL1572023 | 0.88 | HCRTR1 (0.60) | HCRTR1HCRTR2MAPK1 | |
| SCHEMBL1571443 | 0.86 | HCRTR1 (0.64) | HCRTR1HCRTR2 | |
| SCHEMBL1339652 | 0.82 | HCRTR1 (0.54) | HCRTR1HCRTR2 | |
| SCHEMBL1571853 | 0.81 | HCRTR2 (0.58) | HCRTR1HCRTR2 | |
| SCHEMBL1572087 | 0.81 | HCRTR2 (0.58) | HCRTR1HCRTR2 | |
| SCHEMBL1572097 | 0.79 | HCRTR1 (0.61) | HCRTR1HCRTR2MAPK1 | |
| SCHEMBL1572160 | 0.79 | HCRTR1 (0.61) | HCRTR1HCRTR2MAPK1 | |
| SCHEMBL1572066 | 0.78 | HSD17B10 (0.38) | HCRTR1HCRTR2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094690-B1 | 2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-04-13 | — | — | EP | disclosed |