Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.66 |
| ▸ | PIK3R1 | P27986 | 20/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15719186 | 0.93 | PIK3CD (0.70) | PIK3CDPIK3R1PIK3CA | |
| SCHEMBL15731703 | 0.93 | PIK3CD (0.70) | PIK3CDPIK3R1PIK3CA | |
| SCHEMBL15719714 | 0.90 | PIK3CD (0.66) | PIK3CDPIK3R1PIK3CA | |
| SCHEMBL17925301 | 0.90 | PIK3CD (0.66) | PIK3CDPIK3R1PIK3CA | |
| SCHEMBL15731749 | 0.89 | PIK3CD (0.63) | PIK3CDPIK3R1PIK3CA | |
| SCHEMBL17925240 | 0.89 | PIK3CD (0.63) | PIK3CDPIK3R1PIK3CA | |
| SCHEMBL15721090 | 0.89 | PIK3CD (0.61) | PIK3CDPIK3R1PIK3CA | |
| SCHEMBL15731748 | 0.89 | PIK3CD (0.61) | PIK3CDPIK3R1PIK3CA | |
| SCHEMBL15718962 | 0.88 | PIK3CD (0.74) | PIK3CDPIK3R1PIK3CA | |
| SCHEMBL15731480 | 0.88 | PIK3CD (0.74) | PIK3CDPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920172-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | Merck Sharp & Dohme Corp. (US) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014075393-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME CORP. (US) | 2014-05-22 | — | — | WO | disclosed |