Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 13/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 13/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572354 | 0.89 | HCRTR1 (0.36) | HCRTR1HCRTR2HTR4MTNR1B | |
| SCHEMBL1571969 | 0.88 | HCRTR2 (0.41) | HCRTR1HCRTR2CYP1A2CYP3A4THPO | |
| SCHEMBL1571898 | 0.88 | HCRTR1 (0.41) | HCRTR1HCRTR2CYP1A2CYP3A4THPO | |
| SCHEMBL1572015 | 0.87 | HCRTR1 (0.54) | HCRTR1HCRTR2 | |
| SCHEMBL1571651 | 0.86 | HCRTR2 (0.41) | HCRTR1HCRTR2LMNASMN1; SMN2 | |
| SCHEMBL1571642 | 0.85 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL1572349 | 0.82 | HCRTR1 (0.58) | HCRTR1HCRTR2 | |
| SCHEMBL924954 | 0.81 | HCRTR1 (0.57) | HCRTR1HCRTR2 | |
| SCHEMBL1572099 | 0.80 | HCRTR1 (0.54) | HCRTR1HCRTR2 | |
| SCHEMBL1571786 | 0.80 | HCRTR1 (0.46) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094690-B1 | 2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-04-13 | — | — | EP | disclosed |