Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 12/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.43 |
| ▸ | CFD | P00746 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1571938 | 1.00 | HCRTR1 (0.43) | HCRTR1HCRTR2CFDNPC1RAB9A | |
| SCHEMBL1572051 | 0.86 | HCRTR1 (0.51) | HCRTR1HCRTR2PIK3CAMTOR | |
| SCHEMBL1572053 | 0.86 | HCRTR1 (0.51) | HCRTR1HCRTR2PIK3CAMTOR | |
| SCHEMBL1571940 | 0.86 | HCRTR1 (0.44) | HCRTR1HCRTR2CFDUBE2MDCUN1D1 | |
| SCHEMBL1572710 | 0.84 | HCRTR1 (0.52) | HCRTR1HCRTR2PIK3CAMTOR | |
| SCHEMBL1572709 | 0.84 | HCRTR1 (0.52) | HCRTR1HCRTR2PIK3CAMTOR | |
| SCHEMBL2128176 | 0.82 | HCRTR1 (0.43) | HCRTR1HCRTR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1572369 | 0.81 | HCRTR1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL1572367 | 0.81 | HCRTR1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL1572624 | 0.80 | HCRTR1 (0.42) | HCRTR1HCRTR2UBE2MDCUN1D1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288435-B2 | 2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-10-16 | — | — | US | claimed |
| EP-2094690-B1 | 2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-04-13 | — | — | EP | claimed |
| US-8288435-B2 | 2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-10-16 | — | — | US | disclosed |