Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 15/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15731593 | 0.86 | ADORA1 (0.64) | PIK3CDPIK3R1ADORA1 | |
| SCHEMBL15720991 | 0.86 | ADORA1 (0.64) | PIK3CDPIK3R1ADORA1 | |
| SCHEMBL15720245 | 0.80 | PIK3CD (0.60) | PIK3CDPIK3R1PIK3CAPDE4APDE4B | |
| SCHEMBL15719998 | 0.78 | PIK3CD (0.57) | PIK3CDPIK3R1PIK3CAPDE4APDE4B | |
| SCHEMBL31023466 | 0.77 | ADORA1 (0.48) | PIK3CDPIK3R1ADORA1 | |
| SCHEMBL17925202 | 0.76 | PIK3CD (0.85) | PIK3CDPIK3R1 | |
| SCHEMBL15719125 | 0.76 | PIK3CD (0.57) | PIK3CDPIK3R1 | |
| SCHEMBL15731456 | 0.75 | PIK3CD (0.69) | PIK3CDPIK3R1ADORA1 | |
| SCHEMBL17925187 | 0.74 | PIK3CD (0.85) | PIK3CDPIK3R1PIK3CAPDE4APDE4B | |
| SCHEMBL15731382 | 0.74 | PIK3CD (0.74) | PIK3CDPIK3R1PIK3CAPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920172-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | Merck Sharp & Dohme Corp. (US) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014075393-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME CORP. (US) | 2014-05-22 | — | — | WO | disclosed |