Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1571201 | 1.00 | HCRTR1 (0.47) | HCRTR1HCRTR2MAPK1ALOX15 | |
| SCHEMBL923501 | 0.90 | HCRTR1 (0.45) | HCRTR1HCRTR2MAPK1 | |
| Hydrochloric Acid SCHEMBL1398882 | 0.81 | MAPK1 (0.48) | HCRTR1HCRTR2MAPK1ALOX15 | |
| SCHEMBL984607 | 0.79 | HCRTR1 (0.46) | HCRTR1HCRTR2MAPK1ALOX15 | |
| SCHEMBL13538936 | 0.78 | HCRTR1 (0.47) | HCRTR1HCRTR2MAPK1 | |
| SCHEMBL1338047 | 0.78 | HCRTR1 (0.47) | HCRTR1HCRTR2MAPK1 | |
| SCHEMBL496272 | 0.77 | HCRTR1 (0.45) | HCRTR1HCRTR2MAPK1 | |
| SCHEMBL12330231 | 0.76 | MAPK1 (0.43) | HCRTR1HCRTR2MAPK1 | |
| SCHEMBL496356 | 0.73 | HCRTR1 (0.43) | HCRTR1HCRTR2MAPK1 | |
| SCHEMBL983349 | 0.71 | HCRTR1 (0.42) | HCRTR1HCRTR2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094690-B1 | 2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-04-13 | — | — | EP | disclosed |