Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 16/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14127720 | 0.80 | ADORA1 (0.61) | ADORA1ADORA2ALMNANUDT1GFER | |
| SCHEMBL4582424 | 0.78 | ADORA1 (0.83) | ADORA1ADORA2AGFERKMT2A | |
| SCHEMBL6980294 | 0.77 | KDM4E (0.52) | ADORA1ADORA2ALMNAKMT2A | |
| SCHEMBL27324019 | 0.77 | MAPT (0.54) | LMNA | |
| SCHEMBL24309649 | 0.77 | ADORA1 (0.63) | ADORA1ADORA2ALMNANUDT1 | |
| SCHEMBL13377688 | 0.77 | ADORA1 (0.57) | ADORA1ADORA2ALMNANUDT1GFER | |
| SCHEMBL7147862 | 0.77 | ADORA1 (0.57) | ADORA1ADORA2ALMNANUDT1 | |
| SCHEMBL508845 | 0.77 | ADORA1 (0.57) | ADORA1ADORA2ALMNANUDT1 | |
| Ammonia Solution, Strong SCHEMBL28877790 | 0.77 | ADORA1 (0.81) | ADORA1ADORA2AGFERKMT2A | |
| SCHEMBL3021383 | 0.77 | ADORA1 (0.59) | ADORA1ADORA2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920153-A1 | 4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFOXIMINE GROUP | Bayer Pharma Aktiengesellschaft (DE) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014076028-A1 | 4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFOXIMINE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-05-22 | — | — | WO | disclosed |