Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 12/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28292851 | 1.00 | GBA1 (0.33) | GBA1GAATHRBGBA2 | |
| SCHEMBL25502558 | 0.86 | GBA1 (0.35) | GBA1GAATHRBGBA2 | |
| SCHEMBL26712628 | 0.85 | CA1 (0.31) | — | |
| SCHEMBL12883632 | 0.81 | ATM (0.32) | GBA1GAAGBA2 | |
| SCHEMBL10205052 | 0.81 | ATM (0.32) | GBA1GAAGBA2 | |
| SCHEMBL25530706 | 0.81 | — | — | |
| SCHEMBL10226710 | 0.81 | — | — | |
| SCHEMBL15929732 | 0.81 | — | — | |
| SCHEMBL10226702 | 0.81 | — | — | |
| SCHEMBL12299425 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925749-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | Bristol-Myers Squibb Company (US) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014078611-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-05-22 | — | — | WO | disclosed |