Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 17/20 | 0.85 |
| ▸ | BRD4 | O60885 | 4/20 | 0.74 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.74 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.56 |
| ▸ | RAD52 | P43351 | 1/20 | 0.55 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PDXK | O00764 | 1/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.53 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.53 |
| ▸ | STK16 | O75716 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675596 | 0.92 | PLK1 (1.00) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL4412882 | 0.87 | PLK1 (0.79) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL12386468 | 0.87 | PLK1 (0.85) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL29377237 | 0.85 | PLK1 (1.00) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL1559146 | 0.85 | PLK1 (1.00) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL1560682 | 0.85 | PLK1 (0.82) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL1675657 | 0.84 | PLK1 (1.00) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL1560010 | 0.84 | PLK1 (0.99) | PLK1BRD4BRDTALKRAD52 | |
| Tak-960 SCHEMBL30047124 | 0.84 | PLK1 (1.00) | PLK1BRD4BRDTRAD52PLK3 | |
| Tak-960 SCHEMBL1560793 | 0.84 | PLK1 (1.00) | PLK1BRD4BRDTRAD52PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205241-B1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2014-05-21 | — | — | EP | disclosed |