Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 14/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 14/20 | 0.37 |
| ▸ | CDK2 | P24941 | 10/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.37 |
| ▸ | CDK9 | P50750 | 9/20 | 0.37 |
| ▸ | CDK7 | P50613 | 9/20 | 0.37 |
| ▸ | CCNH | P51946 | 9/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 8/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11989644 | 0.89 | HSP90AB1 (0.43) | CCNKCDK12CDK2CCNT1CDK9 | |
| SCHEMBL11989645 | 0.87 | CDK7 (0.38) | CCNKCDK12CDK2CCNT1CDK9 | |
| SCHEMBL11989711 | 0.86 | CDK2 (0.39) | CCNKCDK12CDK2CCNT1CDK9 | |
| SCHEMBL11989707 | 0.86 | CDK2 (0.42) | CCNKCDK12CDK2CCNT1CDK9 | |
| SCHEMBL11989646 | 0.86 | CCNK (0.38) | CCNKCDK12CDK2CCNT1CDK9 | |
| SCHEMBL14238585 | 0.86 | CDK2 (0.37) | CCNKCDK12CDK2CCNT1CDK9 | |
| SCHEMBL11989715 | 0.85 | CDK2 (0.49) | CCNKCDK12CDK2CCNT1CDK9 | |
| SCHEMBL16361467 | 0.85 | CDK2 (0.38) | CCNKCDK12CDK2CCNT1CDK9 | |
| SCHEMBL11989719 | 0.85 | CDK2 (0.38) | CCNKCDK12CDK2CCNT1CDK9 | |
| SCHEMBL11989735 | 0.85 | CDK2 (0.40) | CCNKCDK12CDK2CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2815750-A1 | 5-cyano-4-(pyrrolo [2,3b] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2014-12-24 | — | — | EP | disclosed |
| EP-2124951-B1 | 5-CYAN0-4- (PYRROLO[2, 3B]PYRIDINE-3-YL) -PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2014-05-21 | — | — | EP | disclosed |