Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 12/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.39 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.39 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.39 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.39 |
| ▸ | PRKX | P51817 | 1/20 | 0.39 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1571667 | 1.00 | ROCK1 (0.48) | ROCK1KITFLT3ROCK2PRKCD | |
| SCHEMBL1571579 | 0.90 | ROCK1 (0.58) | ROCK1KITFLT3ROCK2PRKCD | |
| SCHEMBL1571580 | 0.90 | ROCK1 (0.58) | ROCK1KITFLT3ROCK2PRKCD | |
| SCHEMBL25834155 | 0.87 | KIT (0.52) | ROCK1KITFLT3ROCK2PRKCD | |
| SCHEMBL1572360 | 0.83 | KIT (0.49) | ROCK1KITFLT3ROCK2PRKCD | |
| SCHEMBL1572362 | 0.83 | KIT (0.49) | ROCK1KITFLT3ROCK2PRKCD | |
| SCHEMBL1571448 | 0.83 | KIT (0.44) | ROCK1KITFLT3ROCK2PRKCD | |
| SCHEMBL1571447 | 0.83 | KIT (0.44) | ROCK1KITFLT3ROCK2PRKCD | |
| SCHEMBL1571493 | 0.82 | KIT (0.46) | ROCK1KITFLT3ROCK2PRKCD | |
| SCHEMBL1571494 | 0.82 | KIT (0.46) | ROCK1KITFLT3ROCK2PRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125744-B1 | CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLONE AND ISOQUINOLINONE DERIVATIVES | SANOFI AVENTIS (FR) | 2011-04-13 | — | — | EP | disclosed |