Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 4/20 | 0.55 |
| ▸ | AKT2 | P31751 | 4/20 | 0.55 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.53 |
| ▸ | PRKCA | P17252 | 3/20 | 0.53 |
| ▸ | PRKCB | P05771 | 2/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
| ▸ | PRKACB | P22694 | 2/20 | 0.53 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.53 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | LATS1 | O95835 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | PRKCH | P24723 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12531544 | 0.89 | ROCK1 (0.53) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL1572737 | 0.86 | AKT1 (0.43) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL1572673 | 0.85 | ROCK1 (0.61) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL1572598 | 0.84 | AKT1 (0.53) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL13601556 | 0.83 | AKT1 (0.41) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL1925181 | 0.82 | AKT1 (0.55) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL1529407 | 0.76 | AKT1 (0.75) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL1529390 | 0.75 | AKT1 (0.74) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL13509109 | 0.75 | AKT1 (0.74) | AKT1AKT2AKT3ROCK1ROCK2 | |
| SCHEMBL1572684 | 0.75 | ROCK1 (0.61) | AKT1AKT2AKT3ROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110129455-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC | 2011-06-02 | — | — | US | claimed |
| US-20110129455-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC | 2011-06-02 | — | — | US | disclosed |
| US-20110129455-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC | 2011-06-02 | — | — | US | disclosed |
| US-20110129455-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC | 2011-06-02 | — | — | US | disclosed |
| EP-2306825-A1 | INHIBITORS OF AKT ACTIVITY | GlaxoSmithKline LLC (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009158371-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLIKE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009158371-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLIKE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110129455-A1 | INHIBITORS OF AKT ACTIVITY | AKT2, AKT1, PI4KB | AKT1 2/4885AKT2 1/4885AKT3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.