Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 18/20 | 0.76 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | YES1 | P07947 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15726213 | 0.99 | MAPK1 (0.75) | MAPK1AURKBNTRK1YES1PIM1 | |
| SCHEMBL15726204 | 0.97 | MAPK1 (0.71) | MAPK1AURKBNTRK1YES1PIM1 | |
| SCHEMBL15726190 | 0.93 | MAPK1 (0.68) | MAPK1AURKBNTRK1YES1PIM1 | |
| SCHEMBL14681492 | 0.91 | MAPK1 (0.64) | MAPK1AURKBNTRK1YES1PIM1 | |
| SCHEMBL14681551 | 0.91 | MAPK1 (0.63) | MAPK1AURKBNTRK1YES1PIM1 | |
| SCHEMBL14681409 | 0.91 | MAPK1 (0.63) | MAPK1AURKBNTRK1YES1PIM1 | |
| SCHEMBL14681407 | 0.89 | MAPK1 (0.61) | MAPK1AURKBNTRK1YES1PIM1 | |
| SCHEMBL14681569 | 0.89 | MAPK1 (0.61) | MAPK1AURKBNTRK1YES1PIM1 | |
| SCHEMBL14681606 | 0.88 | MAPK1 (0.60) | MAPK1AURKBNTRK1YES1PIM1 | |
| SCHEMBL14681567 | 0.88 | MAPK1 (0.59) | MAPK1AURKBNTRK1YES1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2727920-B1 | 1,5-NAPHTHYRIDINE DERIVATIVE OR SALT THEREOF | FUJIFILM CORP (JP) | 2016-11-02 | — | — | EP | disclosed |
| US-8841456-B2 | 1,5-naphthyridine derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2014-09-23 | — | — | US | disclosed |
| US-8841456-B2 | 1,5-naphthyridine derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2014-09-23 | — | — | US | disclosed |
| US-20140142302-A1 | 1,5-NAPHTHYRIDINE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2014-05-22 | — | — | US | disclosed |
| US-20140142302-A1 | 1,5-NAPHTHYRIDINE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142302-A1 | 1,5-NAPHTHYRIDINE DERIVATIVE OR SALT THEREOF | NRAS, RAF1, KRAS | MAPK1 4/4885AURKB 3666/4885NTRK1 1567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.