Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estrone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 2/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 8/20 | 1.00 |
| ▸ | HSD17B1 | P14061 | 7/20 | 1.00 |
| ▸ | STS | P08842 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 2/20 | 1.00 |
| ▸ | AKR1B10 | O60218 | 1/20 | 1.00 |
| ▸ | SHBG | P04278 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | SERPINA6 | P08185 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | AR | P10275 | 1/20 | 1.00 |
| ▸ | AKR1B1 | P15121 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
| ▸ | SNCA | P37840 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estrone SCHEMBL29621709 | 1.00 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL13153301 | 1.00 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL29373834 | 1.00 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL31398229 | 1.00 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL12054811 | 1.00 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL5028951 | 1.00 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL7831317 | 1.00 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL15079288 | 1.00 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL12822081 | 1.00 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT | |
| Estrone SCHEMBL10039359 | 1.00 | CYP19A1 (1.00) | CYP19A1HSD17B1STSLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2256 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104381251-B | A kind of pesticide micro capsule using the chelate of metal ion of tannic acid as cyst wall and preparation method thereof | SHANDONG AGRICULTURAL UNIVERSITY (CN) | 2016-04-27 | — | — | CN | claimed |
| CN-105377040-A | Pesticidal mixtures | BASF SE | 2016-03-02 | — | — | CN | claimed |
| CN-105340885-A | Cockroach killing soft capsule and preparation method thereof | ANHUI KANGYU BIOLOG TECHNICS PROJECT CO LTD | 2016-02-24 | — | — | CN | claimed |
| CN-103997891-B | As the aromatic phosphoric ester of agrochemicals preparation component | SYNGENTA LTD. (GB) | 2016-02-10 | — | — | CN | claimed |
| CN-105165494-A | Comprehensive prevention method for mulberry field insect pests | INST OF PLANT PROT GUANGXI ACADEMY OF AGRICULTURAL SCIENCES | 2015-12-23 | — | — | CN | claimed |
| CN-105165845-A | Active substance combination based on trifluorobutinyl compounds and exhibiting nematicidal and insecticidal properties | MAKHTESHIM CHEM WORKS LTD | 2015-12-23 | — | — | CN | claimed |
| CN-105142405-A | Synergistic composition comprising a bacillus subtilis strain and a pesticide | BASF SE | 2015-12-09 | — | — | CN | claimed |
| CN-105072915-A | Synergistic compositions comprising a bacillus subtilis strain and a biopesticide | BASF SE | 2015-11-18 | — | — | CN | claimed |
| CN-105050406-A | Composition comprising triazole compound | BASF SE | 2015-11-11 | — | — | CN | claimed |
| CN-105025722-A | Compositions comprising biological control agents and pesticides | BAYER CROPSCIENCE AG | 2015-11-04 | — | — | CN | claimed |
| EP-0158902-B1 | MONOCHROMATIC REPRESENTATION OF COLOR IMAGES | WANG LABORATORIES INC. (US) | 1992-08-19 | — | — | EP | claimed |
| EP-0147041-B1 | ERROR PROTECTION APPARATUS | Laser Magnetic Storage International Company (US) | 1991-04-24 | — | — | EP | claimed |
| EP-0157202-B1 | DIGITAL PWMED PULSE GENERATOR | Kabushiki Kaisha Meidensha (JP) | 1989-10-04 | — | — | EP | claimed |
| EP-0070060-B1 | DISPLAY TUBE | PHILIPS ELECTRONICS UK LIMITED (GB) | 1989-03-01 | — | — | EP | claimed |
| CN-87104588-A | Slow-releasing agent for killing larvel mosquito | — | 1988-03-16 | — | — | CN | claimed |
| CN-86105439-A | Plant protection composition | — | 1988-03-09 | — | — | CN | claimed |
| EP-0204011-A1 | Aggregate with through flow by a fluid | Eickmann, Karl (DE) | 1986-12-10 | — | — | EP | claimed |
| EP-0058536-B1 | DOSE METERING PLUNGER DEVICES FOR USE WITH SYRINGES | Turner, Robert Charles (GB) | 1986-04-16 | — | — | EP | claimed |
| EP-0018013-A1 | Strain gauge bridge circuit | SIEMENS AKTIENGESELLSCHAFT (DE) | 1980-10-29 | — | — | EP | claimed |
| WO-1980000506-A1 | MONITORING DEVICE OF A RUDDER CONTROL UNIT | ANSCHUETZ & CO GMBH (DE) | 1980-03-20 | — | — | WO | claimed |