Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572835 | 1.00 | HCRTR1 (0.48) | HCRTR1HCRTR2 | |
| SCHEMBL3248850 | 0.92 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL1572128 | 0.90 | HCRTR1 (0.55) | HCRTR1HCRTR2 | |
| SCHEMBL1572299 | 0.90 | HCRTR1 (0.55) | HCRTR1HCRTR2 | |
| SCHEMBL1572124 | 0.90 | HCRTR1 (0.55) | HCRTR1HCRTR2 | |
| SCHEMBL1572196 | 0.89 | HCRTR1 (0.52) | HCRTR1HCRTR2 | |
| SCHEMBL1572485 | 0.89 | HCRTR1 (0.52) | HCRTR1HCRTR2 | |
| SCHEMBL1572506 | 0.88 | HCRTR1 (0.52) | HCRTR1HCRTR2 | |
| SCHEMBL1572508 | 0.88 | HCRTR1 (0.52) | HCRTR1HCRTR2 | |
| SCHEMBL1572618 | 0.87 | HCRTR1 (0.46) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288435-B2 | 2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-10-16 | — | — | US | claimed |
| EP-2094690-B1 | 2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-04-13 | — | — | EP | claimed |
| US-8288435-B2 | 2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-10-16 | — | — | US | disclosed |