Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 8/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573268 | 0.88 | CHRM3 (0.57) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5109071 | 0.85 | CHRM1 (0.47) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5109070 | 0.85 | CHRM1 (0.47) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5426186 | 0.82 | CHRM3 (0.50) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5426183 | 0.82 | CHRM3 (0.50) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL3817192 | 0.82 | CHRM2 (0.44) | CHRM3CHRM2CHRM1 | |
| SCHEMBL5099803 | 0.82 | CHRM2 (0.44) | CHRM3CHRM2CHRM1 | |
| SCHEMBL5096174 | 0.82 | CHRM1 (0.46) | CHRM3CHRM2CHRM1DRD2SLC6A2 | |
| SCHEMBL5096172 | 0.82 | CHRM1 (0.46) | CHRM3CHRM2CHRM1DRD2SLC6A2 | |
| SCHEMBL5096072 | 0.75 | CHRM1 (0.55) | CHRM3CHRM2CHRM1ADRA2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888064-B1 | BENZTROPINAMINE ANALOGS AS DOPAMINE UPTAKE INHIBITORS | US GOV HEALTH & HUMAN SERV (US) | 2011-04-13 | — | — | EP | disclosed |