Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | BIRC5 | O15392 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1551547 | 0.90 | PIK3CA (0.47) | PIK3CAMTORGSK3AGSK3BDYRK1A | |
| SCHEMBL953924 | 0.80 | PIK3CA (0.43) | PIK3CAMTORGSK3AGSK3BDYRK1A | |
| SCHEMBL15744127 | 0.77 | PIK3CA (0.48) | PIK3CAMTORGSK3AGSK3BDYRK1A | |
| SCHEMBL15935926 | 0.77 | PIK3CA (0.40) | PIK3CAMTORGSK3AGSK3BDYRK1A | |
| SCHEMBL6750712 | 0.76 | PIK3CA (0.50) | PIK3CAMTORGSK3AGSK3BDYRK1A | |
| SCHEMBL6726880 | 0.75 | PIK3CA (0.48) | PIK3CAMTORGSK3BALDH1A1HPGD | |
| SCHEMBL1552141 | 0.75 | PIK3CA (0.71) | PIK3CAMTORRAB9ANPC1KDM4E | |
| SCHEMBL6748729 | 0.75 | PIK3CA (0.68) | PIK3CAMTORRAB9ANPC1 | |
| SCHEMBL6726819 | 0.74 | PIK3CA (0.37) | PIK3CAMTORGAAALDH1A1RAB9A | |
| SCHEMBL1551119 | 0.74 | PIK3CA (0.46) | PIK3CAMTORGSK3AGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313399-B1 | THIOPHENE OR THIAZOLE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS | MILLENNIUM PHARM INC (US) | 2014-05-28 | — | — | EP | disclosed |