Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMI1 | P35226 | 12/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.40 |
| ▸ | TUBB | P07437 | 2/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15741358 | 0.88 | BMI1 (0.70) | BMI1MAPK1HTTNPC1TSHR | |
| SCHEMBL15747601 | 0.86 | BMI1 (0.64) | BMI1HTTNPC1TSHRRAB9A | |
| SCHEMBL15741354 | 0.84 | BMI1 (0.72) | BMI1MAPK1HTTNPC1TSHR | |
| SCHEMBL15747602 | 0.84 | BMI1 (0.62) | BMI1HTTNPC1TSHRRAB9A | |
| SCHEMBL16748515 | 0.83 | BMI1 (1.00) | BMI1 | |
| SCHEMBL16739757 | 0.81 | BMI1 (0.61) | BMI1MAPK1HTTNPC1TSHR | |
| SCHEMBL16740088 | 0.81 | BMI1 (0.60) | BMI1MAPK1HTTNPC1TSHR | |
| SCHEMBL22186562 | 0.80 | BMI1 (0.59) | BMI1MAPK1HTTNPC1TSHR | |
| SCHEMBL16739733 | 0.80 | BMI1 (0.65) | BMI1MAPK1HTTTSHRDHODH | |
| SCHEMBL16747902 | 0.79 | BMI1 (0.58) | BMI1HTTNPC1TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014081906-A2 | SUBSTITUTED REVERSE PYRIMIDINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. (US) | 2014-05-30 | — | — | WO | disclosed |