Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 14/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | STK4 | Q13043 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31439307 | 1.00 | MTOR (0.47) | MTORAXLPIK3CACSNK1A1CSNK1D | |
| SCHEMBL14978583 | 0.86 | MTOR (0.44) | MTORAXLPIK3CAPRKDCSTK4 | |
| SCHEMBL14978610 | 0.84 | MTOR (0.42) | MTORAXLPIK3CACSNK1A1CSNK1D | |
| SCHEMBL16086154 | 0.84 | MTOR (0.43) | MTORAXLPIK3CACSNK1A1CSNK1D | |
| SCHEMBL31439343 | 0.82 | MTOR (0.42) | MTORPIK3CACSNK1DGSK3BCSNK1G2 | |
| SCHEMBL15747832 | 0.82 | MTOR (0.42) | MTORPIK3CACSNK1DGSK3BCSNK1G2 | |
| SCHEMBL18807465 | 0.81 | MTOR (0.52) | MTOR | |
| SCHEMBL1025189 | 0.80 | MTOR (0.54) | MTOR | |
| SCHEMBL14978580 | 0.78 | DYRK1A (0.51) | MTOR | |
| SCHEMBL1025549 | 0.76 | MTOR (0.55) | MTORPIK3CACSNK1A1CSNK1DGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2719697-B1 | PYRIDONAPHTHYRIDINE PI3K/MTOR DUAL INHIBITORS AND PREPARATION AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2018-08-01 | — | — | EP | disclosed |
| WO-2014079364-A1 | IMIDAZOLONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | 北京富龙康泰生物技术有限公司 (CN) | 2014-05-30 | — | — | WO | disclosed |