Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.70 |
| ▸ | CDK2 | P24941 | 2/20 | 0.70 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15748978 | 0.90 | EGFR (0.70) | EGFRCDK2JAK2KDRAURKB | |
| SCHEMBL15749077 | 0.90 | EGFR (0.70) | EGFRCDK2JAK2KDRAURKB | |
| SCHEMBL15749185 | 0.90 | EGFR (0.70) | EGFRCDK2JAK2KDRAURKB | |
| SCHEMBL15749014 | 0.88 | EGFR (0.68) | EGFRCDK2JAK2KDRAURKB | |
| SCHEMBL17438391 | 0.88 | EGFR (0.68) | EGFRCDK2JAK2KDRAURKB | |
| SCHEMBL17438392 | 0.88 | EGFR (0.68) | EGFRCDK2JAK2KDRAURKB | |
| SCHEMBL15748906 | 0.88 | EGFR (0.82) | EGFRCDK2JAK2KDRAURKB | |
| SCHEMBL17438431 | 0.87 | EGFR (0.67) | EGFRCDK2JAK2KDRAURKB | |
| SCHEMBL15742126 | 0.87 | EGFR (0.69) | EGFRCDK2JAK2KDRAURKB | |
| SCHEMBL15749107 | 0.87 | EGFR (0.67) | EGFRCDK2JAK2KDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890152-B2 | Aminopyrimidine compounds as inhibitors of T790M containing EGFR mutants | GENENTECH, INC. (US) | 2018-02-13 | — | — | US | claimed |
| EP-2922851-B1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | GENENTECH INC (US) | 2017-07-26 | — | — | EP | claimed |
| EP-3181564-B1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | HOFFMANN LA ROCHE (CH) | 2019-09-18 | — | — | EP | disclosed |
| EP-2922851-B1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | GENENTECH INC (US) | 2017-07-26 | — | — | EP | disclosed |
| EP-3181564-A1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | Genentech, Inc. (US) | 2017-06-21 | — | — | EP | disclosed |
| WO-2014081718-A1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | GENENTECH, INC. (US) | 2014-05-30 | — | — | WO | disclosed |