Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.40 |
| ▸ | FEN1 | P39748 | 6/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.33 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.33 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15750970 | 0.89 | ORAI1 (0.48) | ORAI1ALOX5APFEN1PTGESFGFR2 | |
| SCHEMBL15750945 | 0.89 | ORAI1 (0.47) | ORAI1ALOX5APFEN1PTGESFGFR2 | |
| SCHEMBL15021893 | 0.86 | ALOX5AP (0.41) | POLBALOX5APFEN1FGFR2FGFR3 | |
| SCHEMBL30096546 | 0.86 | ALOX5AP (0.41) | POLBALOX5APFEN1FGFR2FGFR3 | |
| SCHEMBL15021862 | 0.86 | POLB (0.43) | ORAI1POLBPTGESCYP3A4CYP2C9 | |
| SCHEMBL15020466 | 0.85 | ORAI1 (0.63) | ORAI1POLBPTGESCYP3A4CYP2C9 | |
| SCHEMBL15751083 | 0.83 | ALOX5AP (0.46) | ORAI1POLBALOX5APFEN1KMT2A | |
| SCHEMBL15021955 | 0.82 | POLB (0.42) | ORAI1POLBPTGESCYP3A4CYP2C9 | |
| SCHEMBL30096559 | 0.82 | POLB (0.42) | ORAI1POLBPTGESCYP3A4CYP2C9 | |
| SCHEMBL15021880 | 0.81 | ALOX5AP (0.43) | ALOX5APFEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2738172-A1 | New bicyclic compounds as crac channel modulators | Almirall, S.A. (ES) | 2014-06-04 | — | — | EP | disclosed |