SCHEMBL15764211

SCHEMBL15764211

O=C1C(=O)c2ccc(-c3cccc(CO)c3)cc2-c2ccccc21

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.64
LMNA P02545 3/20 0.64
MAPT P10636 3/20 0.64
RAB9A P51151 3/20 0.64
SMN1; SMN2 Q16637 3/20 0.64
MEN1 O00255 2/20 0.64
APAF1 O14727 2/20 0.64
THRB P10828 2/20 0.64
HTT P42858 2/20 0.64
GALK1 P51570 2/20 0.64
BLM P54132 2/20 0.64
KMT2A Q03164 2/20 0.64
NPSR1 Q6W5P4 2/20 0.64
XBP1 P17861 1/20 0.64
PTBP1 P26599 1/20 0.64
SMAD3 P84022 1/20 0.64
ATM Q13315 1/20 0.64
L3MBTL1 Q9Y468 1/20 0.64
ACMSD Q8TDX5 1/20 0.48
CHEK1 O14757 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16601682 0.79 MEN1 (0.55) NPC1LMNAMAPTRAB9ASMN1; SMN2
SCHEMBL9423354 0.79 CHEK1 (0.65) NPC1LMNAMAPTRAB9ASMN1; SMN2
SCHEMBL12553067 0.79 NPC1 (0.77) NPC1LMNAMAPTRAB9ASMN1; SMN2
SCHEMBL15383587 0.79 MEN1 (1.00) NPC1LMNAMAPTRAB9ASMN1; SMN2
SCHEMBL16601844 0.78 NPC1 (0.55) NPC1LMNAMAPTRAB9ASMN1; SMN2
SCHEMBL13487418 0.76 MEN1 (0.79) NPC1LMNAMAPTRAB9ASMN1; SMN2
SCHEMBL13487425 0.76 MEN1 (0.79) NPC1LMNAMAPTRAB9ASMN1; SMN2
SCHEMBL4191589 0.76 PRKCI (0.72) ACMSDPRKCICNR2PTGES2
SCHEMBL6254969 0.75 NPC1 (0.63) NPC1LMNAMAPTRAB9ASMN1; SMN2
SCHEMBL16601788 0.75 BACE1 (0.60) LMNAMAPTSMN1; SMN2MEN1BLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2738612-B1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD OF PRODUCING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KK (JP) 2018-07-11 EP disclosed
US-9383663-B2 Electrophotographic photosensitive member, method of producing electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2016-07-05 US disclosed
US-9383663-B2 Electrophotographic photosensitive member, method of producing electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2016-07-05 US disclosed
US-20140154620-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD OF PRODUCING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2014-06-05 US disclosed
US-20140154620-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD OF PRODUCING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2014-06-05 US disclosed