Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | CA1 | P00915 | 4/20 | 0.56 |
| ▸ | CA2 | P00918 | 4/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CA3 | P07451 | 1/20 | 0.56 |
| ▸ | CA6 | P23280 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.56 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16034285 | 0.94 | GAA (0.62) | GAACA1CA2CA12CA9 | |
| SCHEMBL8622705 | 0.94 | GAA (0.62) | GAACA1CA2CA12CA9 | |
| SCHEMBL6917577 | 0.94 | GAA (0.62) | GAACA1CA2CA12CA9 | |
| SCHEMBL8943269 | 0.94 | GAA (0.62) | GAACA1CA2CA12CA9 | |
| SCHEMBL17982097 | 0.94 | GAA (0.62) | GAACA1CA2CA12CA9 | |
| SCHEMBL18274782 | 0.94 | GAA (0.62) | GAACA1CA2CA12CA9 | |
| SCHEMBL346012 | 0.94 | GAA (0.62) | GAACA1CA2CA12CA9 | |
| SCHEMBL22615914 | 0.94 | GAA (0.62) | GAACA1CA2CA12CA9 | |
| SCHEMBL20583857 | 0.94 | GAA (0.62) | GAACA1CA2CA12CA9 | |
| SCHEMBL10917087 | 0.94 | GAA (0.62) | GAACA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104768962-B | Leaving group is the platinum-like compounds of the malonate derivative containing amino or alkylamino | 北京市丰硕维康技术开发有限责任公司 | 2017-04-05 | — | — | CN | claimed |
| CN-103649100-B | Platinum compound with leaving group of succinic acid derivative containing amino or alkylamino, preparation method and application thereof | 北京市丰硕维康技术开发有限责任公司 | 2016-06-22 | — | — | CN | claimed |
| CN-103703011-B | Platinum compounds with leaving group of hydroxy acid derivative containing amino or alkylamino, and preparation method and application thereof | 北京市丰硕维康技术开发有限责任公司 | 2016-06-22 | — | — | CN | claimed |
| EP-2740738-B1 | PLATINUM COMPOUNDS FOR TREATING CELL PROLIFERATIVE DISEASE, PREPARATION METHODS AND USES THEREOF | BEIJING FSWELCOME TECH DEVELOPMENT CO LTD (CN) | 2018-03-28 | — | — | EP | disclosed |
| CN-104768962-B | Leaving group is the platinum-like compounds of the malonate derivative containing amino or alkylamino | 北京市丰硕维康技术开发有限责任公司 | 2017-04-05 | — | — | CN | disclosed |
| EP-2759547-B1 | PLATINUM COMPOUND HAVING AMINO- OR ALKYLAMINO-CONTAINING SUCCINIC ACID DERIVATIVES AS LEAVING GROUP, PREPARATION METHOD THEREFOR, AND USE THEREOF | BEIJING FSWELCOME TECH DEV CO LTD (CN) | 2017-01-18 | — | — | EP | disclosed |
| CN-103732601-B | The one class treatment platinum compounds of cell proliferation disorders, its preparation method and application | 北京市丰硕维康技术开发有限责任公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-103649100-B | Platinum compound with leaving group of succinic acid derivative containing amino or alkylamino, preparation method and application thereof | 北京市丰硕维康技术开发有限责任公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-103703011-B | Platinum compounds with leaving group of hydroxy acid derivative containing amino or alkylamino, and preparation method and application thereof | 北京市丰硕维康技术开发有限责任公司 | 2016-06-22 | — | — | CN | disclosed |
| EP-2924044-A1 | PLATINUM COMPOUND OF MALONIC ACID DERIVATIVE HAVING LEAVING GROUP CONTAINING AMINO OR ALKYLAMINO | BEIJING FSWELCOME TECHNOLOGY DEVELOPMENT, CO., LTD (CN) | 2015-09-30 | — | — | EP | disclosed |
| EP-2759547-A1 | PLATINUM COMPOUND HAVING AMINO- OR ALKYLAMINO-CONTAINING SUCCINIC ACID DERIVATIVES AS LEAVING GROUP, PREPARATION METHOD THEREFOR, AND USE THEREOF | Beijing Fswelcome Technology Development Co., Ltd (CN) | 2014-07-30 | — | — | EP | disclosed |
| EP-2740738-A1 | PLATINUM COMPOUNDS FOR TREATING CELL PROLIFERATIVE DISEASE, PREPARATION METHODS AND USES THEREOF | Beijing FSwelcome Technology Development Co., Ltd. (CN) | 2014-06-11 | — | — | EP | disclosed |
| CN-102993239-A | Platinum compound of succinic acid derivative with leaving group containing amino or alkylamino | CHEN XIAOPING | 2013-03-27 | — | — | CN | disclosed |
| CN-102863474-A | Platinum compounds for treating cell proliferative diseases and preparation method and application thereof | CHEN XIAOPING | 2013-01-09 | — | — | CN | disclosed |