⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30812605 | 1.00 | — | — | |
| SCHEMBL16235279 | 0.74 | — | — | |
| SCHEMBL31392440 | 0.74 | — | — | |
| SCHEMBL16283741 | 0.74 | — | — | |
| SCHEMBL710187 | 0.74 | — | — | |
| SCHEMBL15583074 | 0.74 | — | — | |
| SCHEMBL15582946 | 0.74 | — | — | |
| SCHEMBL29910731 | 0.74 | — | — | |
| SCHEMBL28860227 | 0.71 | — | — | |
| SCHEMBL16235636 | 0.69 | POLB (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4727540-A2 | FUSED BICYCLIC HETEROCYCLIC OR HETERO ARYL AMIDE COMPOUNDS | Quantx Biosciences US, Inc. (US) | 2026-04-22 | — | — | EP | disclosed |
| US-12371426-B2 | Pyridazine derivatives as SMARCA2/4 degraders | AURIGENE DISCOVERY TECH LTD (IN) | 2025-07-29 | — | — | US | disclosed |
| EP-4549431-A1 | COMPOUND FUNCTIONING AS SMARCA2/4 INHIBITOR AND USE THEREOF | Gan & Lee Pharmaceuticals Co., Ltd. (CN) | 2025-05-07 | — | — | EP | disclosed |
| WO-2025026283-A1 | COMPOUND FOR SELECTIVELY DEGRADING SMARCA2/4 AND USE THEREOF | 甘李药业股份有限公司 | 2025-02-06 | — | — | WO | disclosed |
| CN-119384414-A | Compound used as SMARCA2/4 inhibitor and application thereof | 甘李药业股份有限公司 | 2025-01-28 | — | — | CN | disclosed |
| WO-2024259233-A2 | FUSED BICYCLIC HETEROCYCLIC OR HETERO ARYL AMIDE COMPOUNDS | QUANTX BIOSCIENCES US, INC. (US) | 2024-12-19 | — | — | WO | disclosed |
| CN-112771038-B | Pyridazine derivatives as SMARCA2/4 degrading agents | 奥里吉恩发现科技有限公司 | 2024-09-24 | — | — | CN | disclosed |
| US-20240270734-A1 | Pyridazine Derivatives as SMARCA2/4 Degraders | Aurigene Oncology Technologies Limited (IN) | 2024-08-15 | — | — | US | disclosed |
| WO-2024002375-A1 | COMPOUND FUNCTIONING AS SMARCA2/4 INHIBITOR AND USE THEREOF | 甘李药业股份有限公司 | 2024-01-04 | — | — | WO | disclosed |
| CN-117304192-A | Preparation process of 6, 8-dibromoimidazo [1,2-b ] pyridazine | 陕西友帮生物医药科技有限公司 | 2023-12-29 | — | — | CN | disclosed |
| WO-2014020041-A1 | COMBINATIONS FOR THE TREATMENT OF CANCER | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-02-06 | — | — | WO | disclosed |
| US-8324211-B2 | 6-Dimethylamino-2-(2-hydroxymethyl-3-{8-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-imidazo[1,2-b]pyridazin-6-yl }-phenyl)-3,4-dihydro-2H-isoquinolin-1-one; asthma, lupus ; inhibit Btk | ROCHE PALO ALTO LLC (US) | 2012-12-04 | — | — | US | disclosed |
| US-8324211-B2 | 6-Dimethylamino-2-(2-hydroxymethyl-3-{8-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-imidazo[1,2-b]pyridazin-6-yl }-phenyl)-3,4-dihydro-2H-isoquinolin-1-one; asthma, lupus ; inhibit Btk | ROCHE PALO ALTO LLC (US) | 2012-12-04 | — | — | US | disclosed |
| US-8324211-B2 | 6-Dimethylamino-2-(2-hydroxymethyl-3-{8-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-imidazo[1,2-b]pyridazin-6-yl }-phenyl)-3,4-dihydro-2H-isoquinolin-1-one; asthma, lupus ; inhibit Btk | ROCHE PALO ALTO LLC (US) | 2012-12-04 | — | — | US | disclosed |
| WO-2012136776-A1 | IMIDAZOPYRIDAZINES AS AKT KINASE INHIBITORS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-10-11 | — | — | WO | disclosed |
| EP-2307413-A1 | NOVEL PHENYL-IMIDAZOPYRIDINES AND PYRIDAZINES | F. Hoffmann-La Roche AG (CH) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010006947-A1 | NOVEL PHENYL-IMIDAZOPYRIDINES AND PYRIDAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-01-21 | — | — | WO | disclosed |
| US-20100016301-A1 | Inhibitors of bruton's tyrosine kinase | ROCHE PALO ALTO LLC | 2010-01-21 | — | — | US | disclosed |
| US-20100016301-A1 | Inhibitors of bruton's tyrosine kinase | ROCHE PALO ALTO LLC | 2010-01-21 | — | — | US | disclosed |
| US-20100016301-A1 | Inhibitors of bruton's tyrosine kinase | ROCHE PALO ALTO LLC | 2010-01-21 | — | — | US | disclosed |