Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 3/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | ESRRG | P62508 | 6/20 | 0.40 |
| ▸ | ESRRB | O95718 | 3/20 | 0.40 |
| ▸ | F12 | P00748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12498931 | 1.00 | HDAC4 (0.60) | HDAC4KDM4EALDH1A1MAPTPKM | |
| SCHEMBL12499493 | 0.85 | HDAC4 (0.57) | HDAC4ALDH1A1MMP14ADAMTS5ESR1 | |
| SCHEMBL15768686 | 0.85 | HDAC4 (0.57) | HDAC4ALDH1A1MMP14ADAMTS5ESR1 | |
| SCHEMBL12499403 | 0.80 | HDAC4 (0.60) | HDAC4ALDH1A1MMP14ADAMTS5 | |
| SCHEMBL15768615 | 0.80 | HDAC4 (0.60) | HDAC4ALDH1A1MMP14ADAMTS5 | |
| SCHEMBL15769047 | 0.79 | HDAC4 (0.61) | HDAC4ALDH1A1MMP14ADAMTS5 | |
| SCHEMBL12499048 | 0.79 | HDAC4 (0.61) | HDAC4ALDH1A1MMP14ADAMTS5 | |
| SCHEMBL15768585 | 0.75 | HDAC4 (0.61) | HDAC4ALDH1A1MAPTMMP14ADAMTS5 | |
| SCHEMBL12498351 | 0.75 | HDAC4 (0.61) | HDAC4ALDH1A1MAPTMMP14ADAMTS5 | |
| SCHEMBL15768565 | 0.75 | HDAC4 (1.00) | HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765054-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20140163009-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI Foundation (US) | 2014-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163009-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | HDAC1, HDAC7, HDAC5 | HDAC4 10/4885KDM4E 166/4885ALDH1A1 559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.