Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 3/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15569114 | 0.83 | HTT (0.40) | HTTNCOA3MEN1KMT2AKDM4E | |
| SCHEMBL4766762 | 0.79 | APP (0.45) | HTTAPPMEN1KMT2ACYP1A2 | |
| SCHEMBL15009036 | 0.78 | APP (0.57) | GRM5APPMEN1KMT2ACYP1A2 | |
| SCHEMBL29546988 | 0.78 | HTT (0.50) | HTTNCOA3MEN1KMT2AALDH1A1 | |
| SCHEMBL20043 | 0.78 | HTT (0.50) | HTTNCOA3MEN1KMT2AALDH1A1 | |
| SCHEMBL4413712 | 0.76 | CYP1A2 (0.53) | GRM5APPMEN1KMT2ACYP1A2 | |
| SCHEMBL26707958 | 0.76 | MAPT (0.60) | GRM5APPMEN1KMT2ACYP1A2 | |
| SCHEMBL14976350 | 0.76 | GRM5 (0.47) | GRM5APPMEN1KMT2ACYP1A2 | |
| SCHEMBL26703114 | 0.76 | MAPT (0.60) | GRM5APPMEN1KMT2ACYP1A2 | |
| SCHEMBL1921794 | 0.76 | GRM5 (0.47) | GRM5APPMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |