Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 17/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2384309 | 0.91 | PDE10A (0.64) | PDE10A | |
| SCHEMBL2384493 | 0.78 | PDE10A (0.71) | PDE10AMAPT | |
| SCHEMBL2397245 | 0.78 | PDE10A (0.66) | PDE10ATP53RAB9A | |
| SCHEMBL2400200 | 0.77 | PDE10A (0.67) | PDE10A | |
| SCHEMBL2397398 | 0.77 | PDE10A (0.63) | PDE10ARAB9AKMT2A | |
| SCHEMBL2386816 | 0.77 | PDE10A (0.60) | PDE10A | |
| SCHEMBL2401858 | 0.77 | PDE10A (0.64) | PDE10AKMT2A | |
| SCHEMBL2396915 | 0.77 | PDE10A (0.64) | PDE10A | |
| SCHEMBL2387936 | 0.77 | PDE10A (0.64) | PDE10A | |
| SCHEMBL2384492 | 0.77 | PDE10A (0.64) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552918-B1 | N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDE DERIVATIVES AND THEIR USE AS PDE10A INHIBITORS | HOFFMANN LA ROCHE (CH) | 2014-06-11 | — | — | EP | disclosed |