Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.41 |
| ▸ | SELE | P16581 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10253888 | 0.89 | ICAM1 (0.44) | TSHRMAPTICAM1SELEKMT2A | |
| SCHEMBL2663741 | 0.87 | ICAM1 (0.39) | TSHRMAPTLMNAICAM1SELE | |
| SCHEMBL642969 | 0.83 | ICAM1 (0.41) | TSHRMAPTICAM1SELEKMT2A | |
| SCHEMBL644036 | 0.77 | TSHR (0.43) | TSHRMAPTLMNAALDH1A1MEN1 | |
| SCHEMBL9473505 | 0.75 | TSHR (0.59) | TSHRMAPTLMNANPSR1ALDH1A1 | |
| SCHEMBL642036 | 0.74 | CA12 (0.54) | TSHRMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL13131916 | 0.74 | PTGER4 (0.41) | TSHRMAPTLMNAALDH1A1KMT2A | |
| SCHEMBL2663748 | 0.73 | ICAM1 (0.44) | TSHRMAPTLMNAICAM1SELE | |
| SCHEMBL10253414 | 0.73 | ICAM1 (0.50) | MAPTICAM1SELEALDH1A1KMT2A | |
| SCHEMBL12101423 | 0.73 | SLC6A4 (0.42) | TSHRMAPTLMNAICAM1SELE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-B1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | PFIZER PROD INC (US) | 2014-06-11 | — | — | EP | disclosed |