Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 1/20 | 0.54 |
| ▸ | CDK7 | P50613 | 13/20 | 0.50 |
| ▸ | CDK2 | P24941 | 9/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.45 |
| ▸ | CLK2 | P49760 | 3/20 | 0.45 |
| ▸ | CLK3 | P49761 | 3/20 | 0.45 |
| ▸ | WNT1 | P04628 | 1/20 | 0.42 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15799000 | 1.00 | CCNC (0.54) | CCNCCDK8CDK7CDK2DYRK1A | |
| SCHEMBL15799002 | 1.00 | CCNC (0.54) | CCNCCDK8CDK7CDK2DYRK1A | |
| SCHEMBL15799173 | 0.90 | CCNC (0.53) | CCNCCDK8CDK7CDK2DYRK1A | |
| SCHEMBL15799174 | 0.90 | CCNC (0.53) | CCNCCDK8CDK7CDK2DYRK1A | |
| SCHEMBL15799175 | 0.90 | CCNC (0.53) | CCNCCDK8CDK7CDK2DYRK1A | |
| SCHEMBL15806946 | 0.89 | CCNC (0.48) | CCNCCDK8CDK7CDK2DYRK1A | |
| SCHEMBL15799080 | 0.88 | CCNC (0.68) | CCNCCDK8CDK7CDK2DYRK1A | |
| SCHEMBL15799081 | 0.88 | CCNC (0.68) | CCNCCDK8CDK7CDK2DYRK1A | |
| SCHEMBL15799296 | 0.85 | CDK7 (0.53) | CCNCCDK8CDK7CDK2DYRK1A | |
| SCHEMBL15799299 | 0.85 | CDK7 (0.53) | CCNCCDK8CDK7CDK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150266878-A1 | NOVEL BI-RING PHENYL-PYRIDINES/PYRAZINES FOR THE TREATMENT OF CANCER | HOFFMANN-LA ROCHE INC. (US) | 2015-09-24 | — | — | US | claimed |
| EP-2928893-A1 | NOVEL BI-RING PHENYL-PYRIDINES/PYRAZINES FOR THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2015-10-14 | — | — | EP | disclosed |
| US-20150266878-A1 | NOVEL BI-RING PHENYL-PYRIDINES/PYRAZINES FOR THE TREATMENT OF CANCER | HOFFMANN-LA ROCHE INC. (US) | 2015-09-24 | — | — | US | disclosed |
| WO-2014090692-A1 | NOVEL BI-RING PHENYL-PYRIDINES/PYRAZINES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2014-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266878-A1 | NOVEL BI-RING PHENYL-PYRIDINES/PYRAZINES FOR THE TREATMENT OF CANCER | RB1, TP53, BRD4 | CCNC 137/4885CDK8 384/4885CDK7 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.