Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | VNN1 | O95497 | 2/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15793817 | 1.00 | KMT2A (0.32) | KMT2AGPR119MEN1NPC1RAB9A | |
| SCHEMBL15794433 | 1.00 | KMT2A (0.32) | KMT2AGPR119MEN1NPC1RAB9A | |
| SCHEMBL15793743 | 1.00 | KMT2A (0.32) | KMT2AGPR119MEN1NPC1RAB9A | |
| SCHEMBL15794146 | 1.00 | KMT2A (0.32) | KMT2AGPR119MEN1NPC1RAB9A | |
| SCHEMBL15806356 | 0.85 | HRH3 (0.31) | — | |
| SCHEMBL14814818 | 0.85 | HRH3 (0.36) | GPR119OPRK1KCNH2 | |
| SCHEMBL15793575 | 0.83 | HRH3 (0.38) | GPR119 | |
| SCHEMBL15798576 | 0.83 | SCN9A (0.40) | KMT2AMEN1VNN1KCNH2 | |
| SCHEMBL15793446 | 0.83 | SCN9A (0.40) | KMT2AMEN1VNN1KCNH2 | |
| SCHEMBL15794214 | 0.83 | SCN9A (0.40) | KMT2AMEN1VNN1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931727-A1 | DIAZEPINE DERIVATIVES USEFUL AS CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN | Abbvie Inc. (US) | 2015-10-21 | — | — | EP | disclosed |
| WO-2014093337-A1 | DIAZEPINE DERIVATIVES USEFUL AS CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN | ABBVIE, INC. (US) | 2014-06-19 | — | — | WO | disclosed |