Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15794006 | 1.00 | HRH3 (0.39) | HRH3KDM4EABL1LMNAKMT2A | |
| SCHEMBL15793422 | 1.00 | HRH3 (0.39) | HRH3KDM4EABL1LMNAKMT2A | |
| SCHEMBL15793634 | 1.00 | HRH3 (0.39) | HRH3KDM4EABL1LMNAKMT2A | |
| SCHEMBL15794425 | 1.00 | HRH3 (0.39) | HRH3KDM4EABL1LMNAKMT2A | |
| SCHEMBL14815115 | 0.95 | HRH3 (0.40) | HRH3KDM4EABL1LMNALIPG | |
| SCHEMBL15794271 | 0.84 | HRH3 (0.39) | HRH3KDM4EABL1LMNALIPG | |
| SCHEMBL15793592 | 0.84 | HRH3 (0.39) | HRH3KDM4EABL1LMNALIPG | |
| SCHEMBL15793449 | 0.84 | HRH3 (0.39) | HRH3KDM4EABL1LMNALIPG | |
| SCHEMBL15798409 | 0.84 | HRH3 (0.39) | HRH3KDM4EABL1LMNALIPG | |
| SCHEMBL15793857 | 0.84 | HRH3 (0.39) | HRH3KDM4EABL1LMNALIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931727-A1 | DIAZEPINE DERIVATIVES USEFUL AS CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN | Abbvie Inc. (US) | 2015-10-21 | — | — | EP | disclosed |
| WO-2014093337-A1 | DIAZEPINE DERIVATIVES USEFUL AS CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN | ABBVIE, INC. (US) | 2014-06-19 | — | — | WO | disclosed |