Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.49 |
| ▸ | SCN10A | Q9Y5Y9 | 5/20 | 0.45 |
| ▸ | SCN7A | Q01118 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15794010 | 1.00 | SCN9A (0.49) | SCN9ASCN10ASCN7AKCNH2SCN5A | |
| SCHEMBL15794143 | 1.00 | SCN9A (0.49) | SCN9ASCN10ASCN7AKCNH2SCN5A | |
| SCHEMBL15794578 | 1.00 | SCN9A (0.49) | SCN9ASCN10ASCN7AKCNH2SCN5A | |
| SCHEMBL15793574 | 1.00 | SCN9A (0.49) | SCN9ASCN10ASCN7AKCNH2SCN5A | |
| SCHEMBL14814865 | 0.96 | SCN9A (0.50) | SCN9ASCN10ASCN7AKCNH2SCN5A | |
| SCHEMBL15794005 | 0.90 | PDE2A (0.43) | SCN9ASCN10AKCNH2 | |
| SCHEMBL15793952 | 0.90 | PDE2A (0.43) | SCN9ASCN10AKCNH2 | |
| SCHEMBL15794203 | 0.90 | PDE2A (0.43) | SCN9ASCN10AKCNH2 | |
| SCHEMBL15793976 | 0.90 | PDE2A (0.43) | SCN9ASCN10AKCNH2 | |
| SCHEMBL14815151 | 0.86 | SCN9A (0.43) | SCN9ASCN10AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931727-A1 | DIAZEPINE DERIVATIVES USEFUL AS CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN | Abbvie Inc. (US) | 2015-10-21 | — | — | EP | disclosed |
| WO-2014093337-A1 | DIAZEPINE DERIVATIVES USEFUL AS CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN | ABBVIE, INC. (US) | 2014-06-19 | — | — | WO | disclosed |