Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15769264 | 1.00 | BACE1 (0.41) | BACE1BACE2LMNASLC6A4KDM1A | |
| SCHEMBL15366624 | 0.86 | BACE1 (0.54) | BACE1BACE2LMNA | |
| SCHEMBL1934384 | 0.83 | BACE1 (0.47) | BACE1BACE2LMNAKDM1AHRH4 | |
| SCHEMBL1935428 | 0.83 | BACE1 (0.47) | BACE1BACE2LMNAKDM1AHRH4 | |
| SCHEMBL19725852 | 0.78 | BACE1 (0.48) | BACE1BACE2LMNA | |
| SCHEMBL19868131 | 0.75 | BACE1 (0.39) | BACE1BACE2LMNASLC6A4HRH4 | |
| SCHEMBL19868130 | 0.74 | BACE1 (0.43) | BACE1BACE2LMNAKDM1A | |
| SCHEMBL19868234 | 0.74 | BACE1 (0.43) | BACE1BACE2LMNAKDM1A | |
| SCHEMBL1935415 | 0.74 | BACE1 (0.43) | BACE1BACE2LMNAKDM1A | |
| SCHEMBL15768794 | 0.74 | BACE1 (0.38) | BACE1BACE2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931731-A1 | HEXAHYDROPYRANO [3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS AS INHIBITORS OF BACE1 | Pfizer Inc. (US) | 2015-10-21 | — | — | EP | disclosed |
| WO-2014091352-A1 | HEXAHYDROPYRANO [3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS AS INHIBITORS OF BACE1 | PFIZER INC. (US) | 2014-06-19 | — | — | WO | disclosed |