Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 2/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13757061 | 1.00 | GCK (0.50) | GCKJAK1NAMPTMAPTTDP1 | |
| SCHEMBL13757062 | 0.87 | GCK (0.67) | GCKJAK1NAMPTMAPTSMN1; SMN2 | |
| SCHEMBL1581694 | 0.87 | GCK (0.67) | GCKJAK1NAMPTMAPTSMN1; SMN2 | |
| SCHEMBL1582188 | 0.81 | GCK (0.70) | GCK | |
| SCHEMBL12720676 | 0.81 | GCK (0.70) | GCK | |
| SCHEMBL1581938 | 0.81 | NAMPT (0.42) | GCKJAK1NAMPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL13757054 | 0.76 | GCK (0.65) | GCKNAMPTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1581798 | 0.76 | GCK (0.65) | GCKNAMPTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1581787 | 0.73 | NAMPT (0.40) | JAK1NAMPTL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13757089 | 0.72 | GCK (0.72) | GCKSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-B1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | LILLY CO ELI (US) | 2011-04-20 | — | — | EP | disclosed |