Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ISG15 | P05161 | 1/20 | 0.44 |
| ▸ | USP5 | P45974 | 1/20 | 0.44 |
| ▸ | USP16 | Q9Y5T5 | 1/20 | 0.44 |
| ▸ | USP3 | Q9Y6I4 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15817548 | 0.87 | PDE10A (0.48) | PDE10AHDAC6HTR7MEN1KMT2A | |
| SCHEMBL15819541 | 0.84 | ADORA2A (0.46) | PDE10AHDAC6HTR7MEN1KMT2A | |
| SCHEMBL15820749 | 0.83 | USP2 (0.50) | PDE10AUSP2MEN1KMT2ACYP1A2 | |
| SCHEMBL15817404 | 0.83 | PDE10A (0.59) | PDE10AMTNR1AMTNR1BHDAC6USP2 | |
| SCHEMBL18076614 | 0.81 | PDE10A (0.60) | PDE10AHTR7MEN1KMT2ACYP1A2 | |
| SCHEMBL15154005 | 0.80 | PDE10A (0.77) | PDE10AUSP2HTR7MEN1KMT2A | |
| SCHEMBL15820023 | 0.78 | PDE10A (0.44) | PDE10AHDAC6HTR7MEN1KMT2A | |
| SCHEMBL15818503 | 0.77 | PDE10A (0.45) | PDE10AHDAC6L3MBTL1TRPA1 | |
| SCHEMBL15819118 | 0.76 | PIK3CD (0.44) | PDE10A | |
| SCHEMBL15816542 | 0.75 | PIK3CG (0.50) | PDE10AHDAC6SMN1; SMN2KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935246-A1 | ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Calistoga LLC (US) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014100767-A1 | ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD CALISTOGA LLC (US) | 2014-06-26 | — | — | WO | disclosed |