Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.39 |
| ▸ | ISG15 | P05161 | 1/20 | 0.38 |
| ▸ | USP5 | P45974 | 1/20 | 0.38 |
| ▸ | USP16 | Q9Y5T5 | 1/20 | 0.38 |
| ▸ | USP3 | Q9Y6I4 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15819077 | 0.95 | NQO2 (0.43) | HDAC6DRD2NQO2STK17BSTK17A | |
| SCHEMBL15819512 | 0.91 | NQO2 (0.41) | HDAC6NQO2TLR7BRD4PIK3CD | |
| SCHEMBL15819594 | 0.90 | BRD4 (0.40) | HDAC6NQO2PDE7ATLR7BRD4 | |
| SCHEMBL15818376 | 0.86 | PDE10A (0.45) | DRD2STK17BSTK17ABRD4LMNA | |
| SCHEMBL15818996 | 0.86 | STK17B (0.38) | DRD2STK17BSTK17ABRD4GAA | |
| SCHEMBL15818820 | 0.86 | PDE10A (0.48) | LMNA | |
| SCHEMBL15819206 | 0.86 | PLK1 (0.39) | NQO2STK17BSTK17ATLR7BRD4 | |
| SCHEMBL15818524 | 0.85 | NQO2 (0.43) | HDAC6NQO2PDE7ABRD4PIK3CD | |
| SCHEMBL15820457 | 0.85 | NQO2 (0.38) | NQO2STK17BSTK17ABRD4LMNA | |
| SCHEMBL15819357 | 0.84 | NQO2 (0.47) | HDAC6NQO2TLR7BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935246-A1 | ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Calistoga LLC (US) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014100767-A1 | ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD CALISTOGA LLC (US) | 2014-06-26 | — | — | WO | disclosed |