Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2647196 | 0.84 | AKR1C3 (0.48) | AKR1C3PTGS2 | |
| SCHEMBL2647198 | 0.84 | AKR1C3 (0.48) | AKR1C3PTGS2 | |
| SCHEMBL1582010 | 0.84 | AKR1C3 (0.43) | AKR1C3PTGS2ALDH1A1 | |
| SCHEMBL1582012 | 0.84 | AKR1C3 (0.43) | AKR1C3PTGS2ALDH1A1 | |
| SCHEMBL1582057 | 0.82 | AKR1C3 (0.41) | AKR1C3PTGS2ALDH1A1 | |
| SCHEMBL1582055 | 0.82 | AKR1C3 (0.41) | AKR1C3PTGS2ALDH1A1 | |
| SCHEMBL2646235 | 0.79 | AKR1C3 (0.64) | AKR1C3PTGS2 | |
| SCHEMBL2646238 | 0.79 | AKR1C3 (0.64) | AKR1C3PTGS2 | |
| SCHEMBL1582184 | 0.79 | MAPT (0.48) | AKR1C3ALDH1A1 | |
| SCHEMBL1581794 | 0.78 | AKR1C3 (0.43) | AKR1C3PTGS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-B1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | LILLY CO ELI (US) | 2011-04-20 | — | — | EP | disclosed |