⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL277738 | 0.76 | — | — | |
| SCHEMBL2023689 | 0.76 | — | — | |
| SCHEMBL1159492 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL27918220 | 0.73 | — | — | |
| SCHEMBL4397703 | 0.69 | — | — | |
| SCHEMBL20604083 | 0.66 | KMT2A (0.44) | — | |
| SCHEMBL3502009 | 0.65 | — | — | |
| SCHEMBL11667448 | 0.65 | — | — | |
| Propyne SCHEMBL3682365 | 0.65 | — | — | |
| SCHEMBL1083082 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2953947-A1 | 3,5-DIARYLAZAINDOLES AS DYRK1A PROTEIN INHIBITORS FOR THE TREATMENT OF COGNITIVE DEFICIENCES ASSOCIATED WITH DOWN'S SYNDROME AND WITH ALZHEIMER'S DISEASE | Centre National de la Recherche Scientifique (C.N.R.S.) (FR) | 2015-12-16 | — | — | EP | disclosed |
| WO-2014096093-A1 | 3,5-DIARYLAZAINDOLES AS DYRK1A PROTEIN INHIBITORS FOR THE TREATMENT OF COGNITIVE DEFICIENCES ASSOCIATED WITH DOWN'S SYNDROME AND WITH ALZHEIMER'S DISEASE | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2014-06-26 | — | — | WO | disclosed |