Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 3/20 | 0.77 |
| ▸ | CDK2 | P24941 | 3/20 | 0.77 |
| ▸ | IGF1R | P08069 | 6/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12783911 | 0.91 | CCNA2 (0.80) | CCNA2CDK2IGF1RNTRK1 | |
| SCHEMBL12784013 | 0.90 | CCNA2 (0.74) | CCNA2CDK2IGF1RNTRK1NUAK1 | |
| SCHEMBL1164800 | 0.90 | CCNA2 (0.77) | CCNA2CDK2IGF1RNTRK1NUAK1 | |
| SCHEMBL12784003 | 0.90 | CCNA2 (0.71) | CCNA2CDK2IGF1RNTRK1 | |
| SCHEMBL1164659 | 0.90 | CCNA2 (0.71) | CCNA2CDK2IGF1RNTRK1NUAK1 | |
| SCHEMBL12784214 | 0.89 | CCNA2 (0.73) | CCNA2CDK2IGF1RNTRK1NUAK1 | |
| SCHEMBL2069358 | 0.89 | CCNA2 (0.83) | CCNA2CDK2IGF1RNTRK1 | |
| SCHEMBL1165096 | 0.88 | CCNA2 (0.69) | CCNA2CDK2IGF1RNTRK1 | |
| SCHEMBL12784172 | 0.88 | CCNA2 (0.79) | CCNA2CDK2IGF1RNTRK1 | |
| SCHEMBL12784303 | 0.87 | CCNA2 (0.75) | CCNA2CDK2IGF1RNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464641-B1 | PYRIMIDINE COMPOUNDS AS TUBERCULOSIS INHIBITORS | VERTEX PHARMA (US) | 2014-06-25 | — | — | EP | disclosed |