Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15828865 | 0.89 | MAPT (0.62) | PPARGAKR1B1MEN1PTPN7KMT2A | |
| SCHEMBL15828903 | 0.83 | PPARG (0.60) | PPARGAKR1B1MEN1PTPN7KMT2A | |
| SCHEMBL15828896 | 0.80 | KMT2A (0.57) | MEN1KMT2ANPC1LMNAMAPT | |
| SCHEMBL15828895 | 0.77 | MAPT (0.59) | AKR1B1NPC1LMNAMAPT | |
| SCHEMBL20534607 | 0.76 | AKR1B1 (0.78) | PPARGAKR1B1MEN1PTPN7KMT2A | |
| SCHEMBL20534368 | 0.76 | AKR1B1 (0.78) | PPARGAKR1B1MEN1PTPN7KMT2A | |
| SCHEMBL15816052 | 0.76 | MAPK1 (0.64) | PPARGNPC1LMNAMAPT | |
| SCHEMBL15816049 | 0.76 | MAPK1 (0.64) | PPARGNPC1LMNAMAPT | |
| SCHEMBL15816050 | 0.76 | MAPK1 (0.64) | PPARGNPC1LMNAMAPT | |
| SCHEMBL15828907 | 0.74 | CISD1 (0.72) | PPARGMEN1PTPN7KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9115122-B2 | Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK) | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2015-08-25 | — | — | US | disclosed |
| US-20140179743-A1 | NON-ATP DEPENDENT INHIBITORS OF EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2014-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179743-A1 | NON-ATP DEPENDENT INHIBITORS OF EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) | MAPK1, MAP3K1, MAP3K20 | PPARG 4425/4885AKR1B1 1067/4885MEN1 1957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.