Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.84 |
| ▸ | CLK1 | P49759 | 2/20 | 0.79 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.79 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.79 |
| ▸ | CLK2 | P49760 | 2/20 | 0.79 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.79 |
| ▸ | AXL | P30530 | 5/20 | 0.74 |
| ▸ | CDK8 | P49336 | 1/20 | 0.74 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.74 |
| ▸ | SGK1 | O00141 | 1/20 | 0.67 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.66 |
| ▸ | CDC7 | O00311 | 1/20 | 0.64 |
| ▸ | PLK4 | O00444 | 1/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.64 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15833810 | 0.92 | DYRK1A (1.00) | DYRK1ACLK1DYRK2DYRK1BCLK2 | |
| SCHEMBL15833808 | 0.90 | DYRK1A (1.00) | DYRK1ACLK1DYRK2DYRK1BCLK2 | |
| SCHEMBL15833806 | 0.88 | DYRK1A (1.00) | DYRK1ACLK1DYRK2DYRK1BCLK2 | |
| SCHEMBL17211633 | 0.88 | DYRK1A (0.82) | DYRK1ACLK1DYRK2DYRK1BCLK2 | |
| SCHEMBL15833892 | 0.86 | DYRK1A (0.89) | DYRK1ACLK1DYRK2DYRK1BAXL | |
| SCHEMBL3771174 | 0.86 | DYRK1A (0.89) | DYRK1ACLK1DYRK2DYRK1BAXL | |
| SCHEMBL8941685 | 0.85 | AXL (1.00) | DYRK1ACLK1DYRK2DYRK1BCLK2 | |
| SCHEMBL1516702 | 0.85 | AXL (0.76) | DYRK1ACLK1DYRK2DYRK1BCLK2 | |
| SCHEMBL15833800 | 0.83 | AXL (0.73) | DYRK1ACLK1DYRK2DYRK1BCLK2 | |
| SCHEMBL15833807 | 0.83 | DYRK1A (1.00) | DYRK1ACLK1DYRK2DYRK1BCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447093-B2 | 3,5-diarylazaindoles as DYRK1A protein inhibitors for the treatment of cognitive deficiencies associated with Down's syndrome and with Alzheimer's disease | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2016-09-20 | — | — | US | disclosed |
| US-9447093-B2 | 3,5-diarylazaindoles as DYRK1A protein inhibitors for the treatment of cognitive deficiencies associated with Down's syndrome and with Alzheimer's disease | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2016-09-20 | — | — | US | disclosed |
| US-9447093-B2 | 3,5-diarylazaindoles as DYRK1A protein inhibitors for the treatment of cognitive deficiencies associated with Down's syndrome and with Alzheimer's disease | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2016-09-20 | — | — | US | disclosed |
| US-20150307492-A1 | 3,5-Diarylazaindoles as DYRK1A Protein Inhibitors for the Treatment of Cognitive Deficiencies Associated with Down's Syndrome and with Alzheimer's Disease | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-10-29 | — | — | US | disclosed |
| US-20150307492-A1 | 3,5-Diarylazaindoles as DYRK1A Protein Inhibitors for the Treatment of Cognitive Deficiencies Associated with Down's Syndrome and with Alzheimer's Disease | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-10-29 | — | — | US | disclosed |
| US-20150307492-A1 | 3,5-Diarylazaindoles as DYRK1A Protein Inhibitors for the Treatment of Cognitive Deficiencies Associated with Down's Syndrome and with Alzheimer's Disease | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-10-29 | — | — | US | disclosed |
| WO-2014096093-A1 | 3,5-DIARYLAZAINDOLES AS DYRK1A PROTEIN INHIBITORS FOR THE TREATMENT OF COGNITIVE DEFICIENCES ASSOCIATED WITH DOWN'S SYNDROME AND WITH ALZHEIMER'S DISEASE | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307492-A1 | 3,5-Diarylazaindoles as DYRK1A Protein Inhibitors for the Treatment of Cognitive Deficiencies Associated with Down's Syndrome and with Alzheimer's Disease | DYRK1A, DYRK3, DYRK2 | DYRK1A 1/4885CLK1 87/4885DYRK2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.