Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 19/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18673024 | 0.89 | CYP1A2 (0.43) | IRAK4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18673025 | 0.84 | BTK (0.44) | IRAK4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL15834084 | 0.84 | BTK (0.44) | IRAK4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL19633535 | 0.84 | HRH4 (0.51) | IRAK4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL15830289 | 0.83 | MEN1 (0.53) | CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17345683 | 0.82 | MERTK (0.47) | CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL19957823 | 0.82 | MEN1 (0.42) | IRAK4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17308554 | 0.82 | MERTK (0.47) | CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL15833967 | 0.81 | IRAK4 (0.53) | IRAK4CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17303498 | 0.81 | IRAK4 (0.53) | IRAK4CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015200677-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2015-12-30 | — | — | WO | disclosed |
| WO-2014100734-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |