Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | ALPI | P09923 | 1/20 | 0.51 |
| ▸ | ALPG | P10696 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.45 |
| ▸ | STAT3 | P40763 | 2/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2495430 | 0.83 | MAPK1 (0.57) | MAPTALDH1A1MAPK1HSD17B10ALPL | |
| SCHEMBL15840751 | 0.76 | MAPT (0.62) | MAPTALDH1A1MAPK1HSD17B10ALPL | |
| SCHEMBL880408 | 0.76 | MAPT (0.71) | MAPTALDH1A1HSD17B10LMNASMN1; SMN2 | |
| SCHEMBL31457428 | 0.71 | SMN1; SMN2 (0.48) | MAPTALDH1A1MAPK1HSD17B10ALPL | |
| SCHEMBL31457426 | 0.71 | SMN1; SMN2 (0.48) | MAPTALDH1A1MAPK1HSD17B10ALPL | |
| SCHEMBL14942692 | 0.70 | USP2 (0.45) | MAPTALDH1A1MAPK1HSD17B10LMNA | |
| SCHEMBL31457434 | 0.70 | HSD17B10 (0.52) | MAPTALDH1A1MAPK1HSD17B10ALPL | |
| SCHEMBL15840695 | 0.69 | MAPT (0.74) | MAPTALDH1A1MAPK1HSD17B10ALPL | |
| SCHEMBL13310315 | 0.69 | MAPK1 (0.54) | MAPTALDH1A1MAPK1HSD17B10LMNA | |
| SCHEMBL23657938 | 0.69 | MAPK1 (0.57) | MAPTALDH1A1MAPK1HSD17B10ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140179681-A1 | METHODS AND COMPOSITIONS OF TARGETED DRUG DEVELOPMENT | Errico, Joseph P. (US) | 2014-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179681-A1 | METHODS AND COMPOSITIONS OF TARGETED DRUG DEVELOPMENT | EGFR, ERBB2, ERBB3 | MAPT 1076/4885ALDH1A1 4348/4885MAPK1 633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.