Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.39 |
| ▸ | PDE4A | P27815 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10196068 | 0.85 | — | — | |
| SCHEMBL10196198 | 0.85 | — | — | |
| SCHEMBL12386020 | 0.85 | — | — | |
| SCHEMBL25586512 | 0.81 | SYK (0.40) | SYKPDE4AIRAK4 | |
| SCHEMBL8291845 | 0.78 | SYK (0.40) | SYKPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10196511 | 0.74 | SYK (0.39) | SYKPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23277746 | 0.73 | SYK (0.42) | SYK | |
| SCHEMBL23777208 | 0.73 | TSHR (0.41) | SYKPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17471298 | 0.73 | SYK (0.42) | SYK | |
| SCHEMBL19046341 | 0.73 | SYK (0.39) | SYKIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952010-B2 | Amino group-containing pyrrolidinone derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-02-10 | — | — | US | disclosed |
| US-8952010-B2 | Amino group-containing pyrrolidinone derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-02-10 | — | — | US | disclosed |
| US-8952010-B2 | Amino group-containing pyrrolidinone derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-02-10 | — | — | US | disclosed |
| US-20140187542-A1 | AMINO GROUP-CONTAINING PYRROLIDINONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-07-03 | — | — | US | disclosed |
| US-20140187542-A1 | AMINO GROUP-CONTAINING PYRROLIDINONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-07-03 | — | — | US | disclosed |
| US-20140187542-A1 | AMINO GROUP-CONTAINING PYRROLIDINONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-07-03 | — | — | US | disclosed |
| EP-2674430-A1 | AMINO GROUP-CONTAINING PYRROLIDINONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-12-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140187542-A1 | AMINO GROUP-CONTAINING PYRROLIDINONE DERIVATIVE | AR, RCC2, NR3C2 | SYK 3882/4885PDE4A 4409/4885PDE4B 4181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.